Evolutionary design of glutathione-linked proteins in vivo and in vitro based on sampling of modules from pre-existing structures

Evolutionary design of glutathione-linked proteins in vivo and in vitro based on sampling of modules from pre-existing structures

Structural studies suggest that naturally occurring proteins represent a limited number of folds. It would appear that the evolution of novel protein functions to a large extent involves redesign of stable peptide scaffolds by means of combinatorial prote

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Veröffentlicht in:Chemico-biological interactions 2001-02, Vol.133 (1-3), p.3
Hauptverfasser: Mannervik, B, Bolton-Grob, R, Cameron, AD, Etahadieh, M, Gustafsson, A, Hansson, LO, Hubatsch, I, Jemth, P, Johansson, AS, Jones, TA, Larsson, AK, Nilsson, LO, Olin, B, Pettersson, PL, Ridderstrom, M, Stenberg, G, Widersten, M, Wisen, S
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Sprache:eng
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Zusammenfassung:Structural studies suggest that naturally occurring proteins represent a limited number of folds. It would appear that the evolution of novel protein functions to a large extent involves redesign of stable peptide scaffolds by means of combinatorial prote
ISSN:0009-2797
DOI:10.1016/S0009-2797(00)00216-7