Inflammatory functional iron deficiency common in myelofibrosis, contributes to anaemia and impairs quality of life. From the Nordic MPN study Group

Inflammatory functional iron deficiency common in myelofibrosis, contributes to anaemia and impairs quality of life. From the Nordic MPN study Group

Objectives The study investigates the hypothesis that inflammation in myelofibrosis (MF) like in myeloma and lymphoma, may disturb iron distribution and contribute to anaemia. Methods A cross‐sectional study of 80 MF and 23 ET patients was performed. Results About 35% of anaemic MF patients had func...

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Veröffentlicht in:European journal of haematology 2019-03, Vol.102 (3), p.235-240
Hauptverfasser: Birgegard, Gunnar, Samuelsson, Jan, Ahlstrand, Erik, Ejerblad, Elisabeth, Enevold, Christian, Ghanima, Waleed, Hasselbalch, Hans, Nielsen, Claus H., Knutsen, Håvar, Pedersen, Ole B., Sørensen, Anders, Andreasson, Björn
Format: Artikel
Sprache:eng
Schlagworte:
anaemia of inflammation
Anemia
cytokines
Ferritin
functional iron deficiency
Hepcidin
Inflammation
Iron
Iron deficiency
Lymphoma
Myelofibrosis
Myeloma
Nutrient deficiency
Quality of life
Transferrins
Tumor necrosis factor
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Zusammenfassung:Objectives The study investigates the hypothesis that inflammation in myelofibrosis (MF) like in myeloma and lymphoma, may disturb iron distribution and contribute to anaemia. Methods A cross‐sectional study of 80 MF and 23 ET patients was performed. Results About 35% of anaemic MF patients had functional iron deficiency (FID) with transferrin saturation
ISSN:0902-4441
1600-0609
1600-0609
DOI:10.1111/ejh.13198