Clinical and genetic characteristics of late-onset Huntington's disease

The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in...

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Veröffentlicht in:PARKINSONISM & RELATED DISORDERS 2019-04, Vol.61, p.101-105
Hauptverfasser: Oosterloo, Mayke, Bijlsma, Emilia K., van Kuijk, Sander MJ, Minkels, Floor, de Die-Smulders, Christine EM
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Sprache:eng
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Zusammenfassung:The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Participants with late- and common-onset (30–50 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of ≤35 or a UHDRS motor score of ≤5 were excluded. Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P 
ISSN:1353-8020
1873-5126
1873-5126
DOI:10.1016/j.parkreldis.2018.11.009