A non-fatal intoxication and seven deaths involving the dissociative drug 3-MeO-PCP

Highlights • A validated LC-MS/MS method for quantitative analysis of 3-MeO-PCP is described. • 3-MeO-PCP continues to be abused in Sweden despite being scheduled. • Symptoms include tachypnea, tachycardia, hypertension, fever and lactic acidosis. • 3-MeO-PCP half-life was approximately 11 h and con...

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Veröffentlicht in:	Forensic science international 2017-06, Vol.275, p.76-82
Hauptverfasser:	Johansson, Anna, Lindstedt, Daniel, Roman, Markus, Thelander, Gunilla, Nielsen, Elisabet I, Lennborn, Ulrica, Sandler, Håkan, Rubertsson, Sten, Ahlner, Johan, Kronstrand, Robert, Kugelberg, Fredrik C
Format:	Artikel
Sprache:	eng
Schlagworte:	3-MeO-PCP Acidosis Adult Affinity Aggressive behavior Agitation Akathisia, Drug-Induced Alcohol Alcoholic beverages Analgesics Arteriosclerosis Assaying Atherosclerosis Autopsy Biocompatibility Blood Blood pressure Brain Brain research Burns Catatonia - chemically induced Chemical synthesis Chemicals Chromatography, Liquid Complications Designer Drugs - adverse effects Designer Drugs - analysis Designer Drugs - poisoning Dissociative drugs Documents Drug abuse Drug addiction Drugs Edema Emergency medical services Female Fever Forensic sciences Gas chromatography Glucose Half-Life Hallucinogens - adverse effects Hallucinogens - analysis Hallucinogens - poisoning Heart Hemorrhage Humans Hypertension - chemically induced Incidence Intoxication Liver Lungs Male Membranes Mental disorders Mucosa Organs Overdose Oxygen Pathology Pharmacokinetics Pharmacology Phencyclidine Phencyclidine - adverse effects Phencyclidine - analogs & derivatives Phencyclidine - analysis Phencyclidine - poisoning Pneumonia Postmortem blood concentrations Process control Process controls Rectum Respiration Resuscitation Saturation Stomach Substance-Related Disorders - diagnosis Tachycardia - chemically induced Tachypnea - chemically induced Tandem Mass Spectrometry Temperature effects Urinary bladder Urine Vomiting Young Adult
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Zusammenfassung:	Highlights • A validated LC-MS/MS method for quantitative analysis of 3-MeO-PCP is described. • 3-MeO-PCP continues to be abused in Sweden despite being scheduled. • Symptoms include tachypnea, tachycardia, hypertension, fever and lactic acidosis. • 3-MeO-PCP half-life was approximately 11 h and confirmed previous data. • In a fatal mono-intoxication the blood concentration of 3-MeO-PCP was 0.38 μg/g.
ISSN:	0379-0738 1872-6283 1872-6283
DOI:	10.1016/j.forsciint.2017.02.034