Effects of dabigatran according to age in atrial fibrillation

ObjectiveThe prevalence of atrial fibrillation (AF) and the risk of stroke and bleeding vary according to age. To estimate effects of dabigatran, compared with warfarin, on stroke, bleeding and mortality in patients with AF in the Randomized Evaluation of Long-Term Anticoagulant Therapy (RE-LY) tria...

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Veröffentlicht in:	Heart (British Cardiac Society) 2017-07, Vol.103 (13), p.1015-1023
Hauptverfasser:	Lauw, Mandy N, Eikelboom, John W, Coppens, Michiel, Wallentin, Lars, Yusuf, Salim, Ezekowitz, Michael, Oldgren, Jonas, Nakamya, Juliet, Wang, Jia, Connolly, Stuart J
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aged Aged, 80 and over Anticoagulants Antithrombins - administration & dosage Antithrombins - adverse effects Atrial Fibrillation - complications Atrial Fibrillation - drug therapy Atrial Fibrillation - epidemiology Cardiac arrhythmia Dabigatran - administration & dosage Dabigatran - adverse effects Dose-Response Relationship, Drug Drug Administration Schedule Female Follow-Up Studies Hemorrhage - chemically induced Hemorrhage - epidemiology Humans Incidence Male Mortality Netherlands - epidemiology Ontario - epidemiology Risk Assessment - methods Risk Factors Stroke Stroke - epidemiology Stroke - etiology Stroke - prevention & control Survival Rate - trends Sweden - epidemiology Time Factors United States - epidemiology
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Zusammenfassung:	ObjectiveThe prevalence of atrial fibrillation (AF) and the risk of stroke and bleeding vary according to age. To estimate effects of dabigatran, compared with warfarin, on stroke, bleeding and mortality in patients with AF in the Randomized Evaluation of Long-Term Anticoagulant Therapy (RE-LY) trial according to age, we analysed treatment effects using age as a continuous variable and using age categories.MethodsRE-LY included 10 855 (59.9%) patients aged
ISSN:	1355-6037 1468-201X 1468-201X
DOI:	10.1136/heartjnl-2016-310358