A simple passive equilibration method for loading carboplatin into pre-formed liposomes incubated with ethanol as a temperature dependent permeability enhancer

A passive equilibration method which relies on addition of candidate drugs to pre-formed liposomes is described as an alternative method for preparing liposome encapsulated drugs. The method is simple, rapid and applicable to liposomes prepared with high (45mol%) or low (60°C. Super-saturated soluti...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of controlled release 2017-04, Vol.252, p.50-61
Hauptverfasser:	Wehbe, Moe, Malhotra, Armaan, Anantha, Malathi, Roosendaal, Jeroen, Leung, Ada W.Y., Plackett, David, Edwards, Katarina, Gilabert-Oriol, Roger, Bally, Marcel B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacokinetics Cancer Carboplatin Carboplatin - administration & dosage Carboplatin - chemistry Carboplatin - pharmacokinetics Cell Line, Tumor Chemistry, Pharmaceutical Cholesterol Cholesterol - chemistry Drug delivery Drug loading DSPC DSPE-PEG DSPG Ethanol Ethanol - chemistry Female Glioblastoma Half-Life Heterografts Humans Liposomes Liposomes - chemistry Mice Nanoparticle Passive equilibration Passive loading Permeability Phosphatidylcholines - chemistry Phosphatidylethanolamines - chemistry Polyethylene Glycols - chemistry Surface Properties Temperature
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A passive equilibration method which relies on addition of candidate drugs to pre-formed liposomes is described as an alternative method for preparing liposome encapsulated drugs. The method is simple, rapid and applicable to liposomes prepared with high (45mol%) or low (60°C. Super-saturated solutions of CBDCA (40mg/mL) can be prepared at 70°C and these are stable in the presence of ethanol even when the temperature is reduced to
ISSN:	0168-3659 1873-4995 1873-4995
DOI:	10.1016/j.jconrel.2017.03.010