Inflammasomes of the intestinal epithelium

Inflammasomes of the intestinal epithelium

Highlights • Intestinal epithelial cells express a large panel of inflammasome components. • Epithelial inflammasomes protect against acute gut infection, dysbiosis, and tumor development. • Epithelial inflammasomes promote removal of compromised epithelial cells from the mucosa. • Inflammasome-depe...

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Veröffentlicht in:Trends in immunology 2015-08, Vol.36 (8), p.442-450
Hauptverfasser: Sellin, Mikael E, Maslowski, Kendle M, Maloy, Kevin J, Hardt, Wolf-Dietrich
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Animals
Apoptosis
Bacteria
caspase-1
Cytokines
Experiments
extrusion
Humans
Immunity, Mucosal
Infections
Inflammasomes - immunology
Inflammatory bowel disease
innate immunity
intestinal epithelial cell (IEC)
Intestinal Mucosa - immunology
Ligands
mucus
NLRP3
Proteins
Rodents
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Beschreibung
Zusammenfassung:Highlights • Intestinal epithelial cells express a large panel of inflammasome components. • Epithelial inflammasomes protect against acute gut infection, dysbiosis, and tumor development. • Epithelial inflammasomes promote removal of compromised epithelial cells from the mucosa. • Inflammasome-dependent cytokines released from epithelial cells shape immune cell populations.
ISSN:1471-4906
1471-4981
1471-4981
DOI:10.1016/j.it.2015.06.002