Branched-chain amino acids are associated with cardiometabolic risk profiles found already in lean, overweight and obese young

Cardiovascular risk is increased in obese subjects. Nevertheless, some overweight and obese remain cardiometabolically healthy (CMH), and normal-weight persons develop cardiovascular disease (CVD). Herein, we investigate the potential of branched-chain amino acids (BCAAs) to identify an increased CV...

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Veröffentlicht in:	The Journal of nutritional biochemistry 2016-06, Vol.32, p.123-127
Hauptverfasser:	Mangge, Harald, Zelzer, Sieglinde, Prüller, Florian, Schnedl, Wolfgang J., Weghuber, Daniel, Enko, Dietmar, Bergsten, Peter, Haybaeck, Johannes, Meinitzer, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Amino Acids, Branched-Chain - blood Austria - epidemiology Biomarkers - blood Body Mass Index Branched-chain amino acids Cardiometabolic risk Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cross-Sectional Studies Female Glucose Metabolism Disorders - epidemiology Glucose Metabolism Disorders - etiology Humans Incidence Insulin Resistance Male Obesity - blood Obesity - metabolism Obesity - physiopathology Obesity, Metabolically Benign - blood Obesity, Metabolically Benign - metabolism Obesity, Metabolically Benign - physiopathology Overweight - blood Overweight - metabolism Overweight - physiopathology Pediatric Obesity - blood Pediatric Obesity - metabolism Pediatric Obesity - physiopathology Prospective Studies Risk Thinness - blood Thinness - metabolism Thinness - physiopathology Young Adult
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Zusammenfassung:	Cardiovascular risk is increased in obese subjects. Nevertheless, some overweight and obese remain cardiometabolically healthy (CMH), and normal-weight persons develop cardiovascular disease (CVD). Herein, we investigate the potential of branched-chain amino acids (BCAAs) to identify an increased CVD risk in a cross-sectional study of 666 adults and juveniles (age 25.3±12.8years), classified as lean, overweight or obese. Cardiometabolic groups were defined by cutoffs of systolic blood pressure
ISSN:	0955-2863 1873-4847 1873-4847
DOI:	10.1016/j.jnutbio.2016.02.007