International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors

The Adhesion family forms a large branch of the pharmacologically important superfamily of G protein–coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention from a wide spectrum of biomedical fields, the Adhesion GPCR Consortium, together with the International Union of Basic and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pharmacological reviews 2015-04, Vol.67 (2), p.338-367
Hauptverfasser:	Hamann, Jörg, Aust, Gabriela, Araç, Demet, Engel, Felix B., Formstone, Caroline, Fredriksson, Robert, Hall, Randy A., Harty, Breanne L., Kirchhoff, Christiane, Knapp, Barbara, Krishnan, Arunkumar, Liebscher, Ines, Lin, Hsi-Hsien, Martinelli, David C., Monk, Kelly R., Peeters, Miriam C., Piao, Xianhua, Prömel, Simone, Schöneberg, Torsten, Schwartz, Thue W., Singer, Kathleen, Stacey, Martin, Ushkaryov, Yuri A., Vallon, Mario, Wolfrum, Uwe, Wright, Mathew W., Xu, Lei, Langenhan, Tobias, Schiöth, Helgi B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Adhesion Cell Adhesion Molecules - chemistry Cell Adhesion Molecules - metabolism Cell Membrane - enzymology Cell Membrane - metabolism Cell Movement Cyclic AMP - physiology Humans International Agencies IUPHAR Nomenclature Reports Ligands Models, Molecular Pharmacology - trends Pharmacology, Clinical - trends Protein Isoforms - agonists Protein Isoforms - chemistry Protein Isoforms - classification Protein Isoforms - metabolism Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - chemistry Receptors, G-Protein-Coupled - classification Receptors, G-Protein-Coupled - metabolism Second Messenger Systems Signal Transduction Societies, Scientific Terminology as Topic
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The Adhesion family forms a large branch of the pharmacologically important superfamily of G protein–coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention from a wide spectrum of biomedical fields, the Adhesion GPCR Consortium, together with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification, proposes a unified nomenclature for Adhesion GPCRs. The new names have ADGR as common dominator followed by a letter and a number to denote each subfamily and subtype, respectively. The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98). This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential.
ISSN:	0031-6997 1521-0081 1521-0081
DOI:	10.1124/pr.114.009647