Interactions between heparan sulfate and proteins: the concept of specificity

Proteoglycan (PG) coreceptors carry heparan sulfate (HS) chains that mediate interactions with growth factors, morphogens, and receptors. Thus, PGs modulate fundamental processes such as cell survival, division, adhesion, migration, and differentiation. This review summarizes recent biochemical and...

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Veröffentlicht in:The Journal of cell biology 2006-07, Vol.174 (3), p.323-327
Hauptverfasser: Kreuger, Johan, Spillmann, Dorothe, Li, Jin-ping, Lindahl, Ulf
Format: Artikel
Sprache:eng
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Zusammenfassung:Proteoglycan (PG) coreceptors carry heparan sulfate (HS) chains that mediate interactions with growth factors, morphogens, and receptors. Thus, PGs modulate fundamental processes such as cell survival, division, adhesion, migration, and differentiation. This review summarizes recent biochemical and genetic information that sheds new light on the nature of HS-protein binding. Unexpectedly, many interactions appear to depend more on the overall organization of HS domains than on their fine structure.
ISSN:0021-9525
1540-8140
1540-8140
DOI:10.1083/jcb.200604035