Synthesis of antimalarial compounds fosmidomycin and FR900098 through N- or P-alkylation reactions

Two straightforward and convenient routes for the synthesis of the antimalarial agents FR900098 and fosmidomycin are described. In the key steps N- or P-alkylation reactions are used. The best overall yields of FR900098 and fosmidomycin in 15 mmol scale are 83% and 68%, respectively. These routes ut...

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Veröffentlicht in:	Tetrahedron 2013-01, Vol.69 (3), p.1183-1188
Hauptverfasser:	Suresh, Surisetti, Shyamraj, Dharavath, Larhed, Mats
Format:	Artikel
Sprache:	eng
Schlagworte:	3 (n acetyl n hydroxyamino)propylphosphonic acid alkylation antimalarial agent drug synthesis Fosmidomycin FR900098 N-alkylation nitrogen P-alkylation phosphorus priority journal unclassified drug
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Two straightforward and convenient routes for the synthesis of the antimalarial agents FR900098 and fosmidomycin are described. In the key steps N- or P-alkylation reactions are used. The best overall yields of FR900098 and fosmidomycin in 15 mmol scale are 83% and 68%, respectively. These routes utilize readily available materials and avoid harsh conditions. [Display omitted]
ISSN:	0040-4020 1464-5416 1464-5416
DOI:	10.1016/j.tet.2012.11.049