Feed-forward mechanisms: Addiction-like behavioral and molecular adaptations in overeating

Graphical abstract Highlights ► Palatable food promotes overeating and weight gain in humans and experimental animals. ► We review evidence for palatability-induced chronic adaptations in reward processing. ► We show that these changes act in a feed-forward manner to promote further overeating. ► Th...

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Veröffentlicht in:	Frontiers in neuroendocrinology 2012-04, Vol.33 (2), p.127-139
Hauptverfasser:	Alsiö, Johan, Olszewski, Pawel K, Levine, Allen S, Schiöth, Helgi B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological - genetics Addiction Animals Behavior, Addictive - etiology Behavior, Addictive - genetics Behavior, Addictive - physiopathology Brain - metabolism Brain - physiopathology Compulsive Behavior - etiology Compulsive Behavior - genetics Compulsive Behavior - physiopathology Craving Dietary fat Endocrinology & Metabolism Feedback, Physiological - physiology Humans Hyperphagia - genetics Hyperphagia - physiopathology Hyperphagia - psychology Models, Cardiovascular Obesity Plasticity Reward Signal Transduction - physiology Substance-Related Disorders - genetics Substance-Related Disorders - physiopathology Sugar
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Beschreibung
Zusammenfassung:	Graphical abstract Highlights ► Palatable food promotes overeating and weight gain in humans and experimental animals. ► We review evidence for palatability-induced chronic adaptations in reward processing. ► We show that these changes act in a feed-forward manner to promote further overeating. ► They contribute to addictive-like eating behavior during withdrawal from palatability. ► This explains why overeating and obesity are oftentimes lifelong adverse conditions.
ISSN:	0091-3022 1095-6808 1095-6808
DOI:	10.1016/j.yfrne.2012.01.002