Non-immunoglobulin based protein scaffolds

Highlights ► Alternative protein scaffolds in biotherapy and molecular imaging. ► Protein scaffolds have unique properties compared to antibodies. ► Non-Ig based protein scaffolds show promise in clinical development. ► Small protein scaffolds are superior to monoclonal antibodies for molecular imag...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Current opinion in biotechnology 2011-12, Vol.22 (6), p.843-848
Hauptverfasser:	Löfblom, John, Frejd, Fredrik Y, Ståhl, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Diagnostic Imaging Humans image analysis Immunoglobulins - chemistry Immunotherapy Internal Medicine monoclonal antibodies pharmacokinetics Proteins - metabolism Proteins - therapeutic use
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights ► Alternative protein scaffolds in biotherapy and molecular imaging. ► Protein scaffolds have unique properties compared to antibodies. ► Non-Ig based protein scaffolds show promise in clinical development. ► Small protein scaffolds are superior to monoclonal antibodies for molecular imaging. ► Approaches for extending in vivo half-life of protein scaffolds are available.
ISSN:	0958-1669 1879-0429 1879-0429
DOI:	10.1016/j.copbio.2011.06.002