Kill the messenger: bacterial antisense RNA promotes mRNA decay

Bacterial antisense RNAs target translation initiation regions (TIRs) to compete with ribosome binding, thus repressing translation and—secondarily—causing degradation of the naked mRNA. A new study reports on an antisense RNA that directly accelerates mRNA decay by targeting a sequence deep within...

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Veröffentlicht in:	Nature structural & molecular biology 2009-08, Vol.16 (8), p.804-806
1. Verfasser:	Wagner, E Gerhart H
Format:	Artikel
Sprache:	eng
Schlagworte:	Antisense RNA Bacteria Bacterial genetics Bacterial Proteins - genetics Bacterial Proteins - metabolism Binding sites Biochemistry Biological Microscopy Biomedical and Life Sciences Clinical genetics Control Decay Dermatologi och venerologi, klinisk genetik, invärtesmedicin Dermatology and venerology,clinical genetics, internal medicine Endoribonucleases - metabolism Health aspects Klinisk genetik Life Sciences MEDICIN MEDICINE Membrane Biology Messenger RNA Models, Biological Molecular biology Molekylärbiologi news-and-views Open Reading Frames - genetics Physiological aspects Porins - genetics Protein biosynthesis Protein Biosynthesis - genetics Protein Structure Proteins Ribonucleic acid RNA RNA Stability RNA, Antisense - genetics RNA, Antisense - metabolism RNA, Bacterial - genetics RNA, Bacterial - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Untranslated - genetics RNA, Untranslated - metabolism Salmonella typhimurium - genetics Salmonella typhimurium - metabolism
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Zusammenfassung:	Bacterial antisense RNAs target translation initiation regions (TIRs) to compete with ribosome binding, thus repressing translation and—secondarily—causing degradation of the naked mRNA. A new study reports on an antisense RNA that directly accelerates mRNA decay by targeting a sequence deep within the coding region, far downstream of the TIR.
ISSN:	1545-9993 1545-9985 1545-9985
DOI:	10.1038/nsmb0809-804