Iridium-catalyzed asymmetric hydrogenation of olefins using TIQ phosphine–oxazoline ligands

Iridium-catalyzed asymmetric hydrogenation of olefins using TIQ phosphine–oxazoline ligands

A novel family of tetrahydroisoquinoline (TIQ) phosphine–oxazoline ligands and four corresponding iridium complexes have been developed and applied to the asymmetric hydrogenation of unfunctionalized olefins. The results showed that the best conversion rates were observed in up to 99% with an enanti...

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Veröffentlicht in:Tetrahedron: asymmetry 2010-09, Vol.21 (18), p.2295-2301
Hauptverfasser: Chakka, Sai Kumar, Peters, Byron K., Andersson, Pher G., Maguire, Glenn E.M., Kruger, Hendrik G., Govender, Thavendran
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Kemi
NATURAL SCIENCES
NATURVETENSKAP
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Zusammenfassung:A novel family of tetrahydroisoquinoline (TIQ) phosphine–oxazoline ligands and four corresponding iridium complexes have been developed and applied to the asymmetric hydrogenation of unfunctionalized olefins. The results showed that the best conversion rates were observed in up to 99% with an enantiomeric excess of 91%.
ISSN:0957-4166
1362-511X
1362-511X
DOI:10.1016/j.tetasy.2010.07.032