Characterization of the neuropeptide Y system in the frog Silurana tropicalis (Pipidae): Three peptides and six receptor subtypes

Highlights ► The Western clawed frog has six of the ancestral seven gnathostome receptors. ► Binding studies show interesting differences to mammals in peptide–receptor preferences. ► The peptides and receptors are widely expressed, notably in skin. ► NPY was detected in brain like in all other vert...

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Veröffentlicht in:	General and comparative endocrinology 2012-07, Vol.177 (3), p.322-331
Hauptverfasser:	Sundström, G, Xu, B, Larsson, T.A, Heldin, J, Bergqvist, C.A, Fredriksson, R, Conlon, J.M, Lundell, I, Denver, R.J, Larhammar, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Amniota Animals Anura appetite blood brain chickens Endocrinology & Metabolism evolution feeding behavior frogs G-protein coupled receptors G-protein-coupled receptor genes heart mammals messenger RNA muscles neuropeptide Y Neuropeptide Y - classification Neuropeptide Y - genetics Neuropeptide Y - metabolism NPY Pancreatic polypeptide peptide receptors Peptide YY - classification Peptide YY - genetics Peptide YY - metabolism Phylogeny Pipidae Pipidae - genetics Pipidae - metabolism PYY Receptors, G-Protein-Coupled - classification Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Receptors, Neuropeptide Y - classification Receptors, Neuropeptide Y - genetics Receptors, Neuropeptide Y - metabolism reverse transcriptase polymerase chain reaction Silurana tropicalis small intestine Xenopus tropicalis
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Beschreibung
Zusammenfassung:	Highlights ► The Western clawed frog has six of the ancestral seven gnathostome receptors. ► Binding studies show interesting differences to mammals in peptide–receptor preferences. ► The peptides and receptors are widely expressed, notably in skin. ► NPY was detected in brain like in all other vertebrates investigated. ► PYY was not detected in brain, as in mammals but in contrast to fish, nor was PP.
ISSN:	0016-6480 1095-6840 1095-6840
DOI:	10.1016/j.ygcen.2012.04.027