Early life origins of chronic obstructive pulmonary disease

Background:Early life development may influence subsequent respiratory morbidity. The impact of factors determined in childhood on adult lung function, decline in lung function and chronic obstructive pulmonary disease (COPD) was investigated.Methods:European Community Respiratory Health Survey part...

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Veröffentlicht in:	Thorax 2010-01, Vol.65 (1), p.14-20
Hauptverfasser:	Svanes, C, Sunyer, J, Plana, E, Dharmage, S, Heinrich, J, Jarvis, D, de Marco, R, Norbäck, D, Raherison, C, Villani, S, Wjst, M, Svanes, K, Antó, J M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adults Age Age of Onset Allergens Asthma Asthma - complications Asthma - epidemiology Asthma - physiopathology Biological and medical sciences Body mass index Cardiology. Vascular system Childrens health Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease, asthma Epidemiologic Methods Female Forced Expiratory Volume - physiology Humans Infections Male Medical sciences MEDICIN MEDICINE Middle Aged Pneumology Pulmonary Disease, Chronic Obstructive - epidemiology Pulmonary Disease, Chronic Obstructive - etiology Pulmonary Disease, Chronic Obstructive - physiopathology Smoking Smoking - adverse effects Social classes Spirometry Vital Capacity - physiology Womens health Young Adult
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Zusammenfassung:	Background:Early life development may influence subsequent respiratory morbidity. The impact of factors determined in childhood on adult lung function, decline in lung function and chronic obstructive pulmonary disease (COPD) was investigated.Methods:European Community Respiratory Health Survey participants aged 20–45 years randomly selected from general populations in 29 centres underwent spirometry in 1991–3 (n = 13 359) and 9 years later (n = 7738). Associations of early life factors with adult forced expiratory volume in 1 s (FEV1), FEV1 decline and COPD (FEV1/FVC ratio
ISSN:	0040-6376 1468-3296 1468-3296
DOI:	10.1136/thx.2008.112136