HIV-1 reverse transcriptase inhibiting antibody titer in serum: Relation to disease progression and to core-antibody levels

A new assay for detecting inhibition of reverse transcriptase activity (the RT‐i REA) was developed. This assay was standardized for screening serum samples for reverse transcriptase inhibiting antibodies (RT‐iAb). High specificity (100%) and sensitivity (

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of medical virology 1992-04, Vol.36 (4), p.283-291
Hauptverfasser:	Neumüller, Magnus, Karlsson, Anders, Lennerstrand, Johan, Källander, Clas F. R., Sandstrdm, Erik, Holmberg, Viveca, Gronowitz, J. Simon
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - immunology AIDS/HIV Biological and medical sciences Female HIV antibodies HIV Antibodies - blood HIV Antibodies - immunology HIV Infections - immunology HIV progression HIV Reverse Transcriptase HIV-1 - enzymology HIV-1 - immunology human immunodeficiency virus 1 Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Longitudinal Studies Male Medical sciences Pregnancy progression marker reverse transcriptase RNA-Directed DNA Polymerase - immunology Viral Core Proteins - immunology
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Beschreibung
Zusammenfassung:	A new assay for detecting inhibition of reverse transcriptase activity (the RT‐i REA) was developed. This assay was standardized for screening serum samples for reverse transcriptase inhibiting antibodies (RT‐iAb). High specificity (100%) and sensitivity (
ISSN:	0146-6615 1096-9071 1096-9071
DOI:	10.1002/jmv.1890360410