Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus

A genetic contribution to the development of systemic lupus erythematosus (SLE) is well established. Several genome-wide linkage scans have identified a number of putative susceptibility loci for SLE, some of which have been replicated in independent samples. This study aimed to identify the regions...

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Veröffentlicht in:	Genes and immunity 2006-10, Vol.7 (7), p.609-614
Hauptverfasser:	Forabosco, P, Gorman, J D, Cleveland, C, Kelly, J A, Fisher, S A, Ortmann, W A, Johansson, C, Johanneson, B, Moser, K L, Gaffney, P M, Tsao, B P, Cantor, R M, Alarcón-Riquelme, M E, Behrens, T W, Harley, J B, Lewis, C M, Criswell, L A
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis Biomedical and Life Sciences Biomedicine Cancer Research Causes of Chromosome 16 Chromosome 6 Chromosomes, Human, Pair 16 - genetics Chromosomes, Human, Pair 20 - genetics Chromosomes, Human, Pair 6 - genetics Disease DNA testing Female Gene Expression Genes Genetic aspects Genetic disorders Genetic diversity Genetic Linkage Genetic Predisposition to Disease Genetics Genome, Human Genome-wide association studies Genomes Histocompatibility antigen HLA HLA Antigens - genetics Human Genetics Humans Immunology Influence linkage Linkage (Genetics) Linkage analysis Lupus Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Male Medical research MEDICIN MEDICINE Meta-analysis Methods Physiological aspects Rheumatology short-communication Single-nucleotide polymorphism SLE Systemic lupus erythematosus Tissue typing White people
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Zusammenfassung:	A genetic contribution to the development of systemic lupus erythematosus (SLE) is well established. Several genome-wide linkage scans have identified a number of putative susceptibility loci for SLE, some of which have been replicated in independent samples. This study aimed to identify the regions showing the most consistent evidence for linkage by applying the genome scan meta-analysis (GSMA) method. The study identified two genome-wide suggestive regions on 6p21.1–q15 and 20p11–q13.13 ( P -value=0.0056 and P -value=0.0044, respectively) and a region with P -value
ISSN:	1466-4879 1476-5470 1476-5470
DOI:	10.1038/sj.gene.6364338