Skin and Plasma Autofluorescence During Hemodialysis: A Pilot Study

Skin autofluorescence (AF) is related to the accumulation of advanced glycation end products (AGEs) and is one of the strongest prognostic markers of mortality in hemodialysis (HD) patients. The aim of this pilot study was to investigate whether changes in skin AF appear after a single HD session an...

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Veröffentlicht in:	Artificial organs 2014-06, Vol.38 (6), p.515-518
Hauptverfasser:	Graaff, Reindert, Arsov, Stefan, Ramsauer, Bernd, Koetsier, Marten, Sundvall, Nils, Engels, Gerwin E., Sikole, Aleksandar, Lundberg, Lennart, Rakhorst, Gerhard, Stegmayr, Bernd
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Advanced glycation end products Aged Aged, 80 and over Biomarkers - blood Case-Control Studies Female Glycation End Products, Advanced - blood Hemodialysis Humans Male Middle Aged Pilot Projects Plasma Plasma autofluorescence Renal Dialysis Skin Skin - metabolism Skin autofluorescence Spectrometry, Fluorescence Time Factors
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Zusammenfassung:	Skin autofluorescence (AF) is related to the accumulation of advanced glycation end products (AGEs) and is one of the strongest prognostic markers of mortality in hemodialysis (HD) patients. The aim of this pilot study was to investigate whether changes in skin AF appear after a single HD session and if they might be related to changes in plasma AF. Skin and plasma AF were measured before and after HD in 35 patients on maintenance HD therapy (nine women and 26 men, median age 68 years, range 33–83). Median dialysis time was 4 h (range 3–5.5). Skin AF was measured noninvasively with an AGE Reader, and plasma AF was measured before and after HD at 460 nm after excitation at 370 nm. The HD patients had on average a 65% higher skin AF value than age‐matched healthy persons (P
ISSN:	0160-564X 1525-1594 1525-1594
DOI:	10.1111/aor.12205