GDNF is important for striatal organization and maintenance of dopamine neurons grown in the presence of the striatum

Highlights • GDNF is essential for survival of the striatum. • GDNF is essential for the striatal organization. • GDNF is important for the dopamine neurons especially in the presence of the striatum.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2014-06, Vol.270, p.1-11
Hauptverfasser:	Chermenina, M, Schouten, P, Nevalainen, N, Johansson, F, Orädd, G, Strömberg, I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain Tissue Transplantation Cell Survival - physiology Corpus Striatum - growth & development Corpus Striatum - physiology Corpus Striatum - surgery DARPP-32 dopamine Dopamine and cAMP-Regulated Phosphoprotein 32 - metabolism Dopaminergic Neurons - physiology Female Fundamental and applied biological sciences. Psychology GDNF GDNF knockout Genotyping Techniques Glial Cell Line-Derived Neurotrophic Factor - genetics Glial Cell Line-Derived Neurotrophic Factor - metabolism Immunohistochemistry Magnetic Resonance Imaging Mesencephalon - embryology Mesencephalon - physiology Mesencephalon - transplantation Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Neurology Neurons - physiology striatum substantia nigra Tyrosine 3-Monooxygenase - metabolism Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights • GDNF is essential for survival of the striatum. • GDNF is essential for the striatal organization. • GDNF is important for the dopamine neurons especially in the presence of the striatum.
ISSN:	0306-4522 1873-7544 1873-7544
DOI:	10.1016/j.neuroscience.2014.04.008