Serotonergic nerve fibers in l -DOPA-derived dopamine release and dyskinesia

Highlights • 5-HT nerve fibers convert levodopa to dopamine in the intact striatum. • Chronic levodopa treatment reduces 5-HT nerve fiber density. • SSRI reduces levodopa-induced dyskinesia via 5-HT1A receptors.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2014-02, Vol.260, p.73-86
Hauptverfasser:	Nevalainen, N, af Bjerkén, S, Gerhardt, G.A, Strömberg, I
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Corpus Striatum - drug effects Dopamine - metabolism dyskinesia Dyskinesia, Drug-Induced - drug therapy Female fluoxetine Fluoxetine - therapeutic use Fundamental and applied biological sciences. Psychology in vivo chronoamperometry l-DOPA Levodopa - pharmacology Medical sciences Nerve Fibers - drug effects Nerve Fibers - metabolism Neurology Neuropharmacology Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Serotonergic Neurons - drug effects Serotonergic Neurons - metabolism Serotonin Plasma Membrane Transport Proteins - metabolism Vertebrates: nervous system and sense organs WAY-100 635
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Beschreibung
Zusammenfassung:	Highlights • 5-HT nerve fibers convert levodopa to dopamine in the intact striatum. • Chronic levodopa treatment reduces 5-HT nerve fiber density. • SSRI reduces levodopa-induced dyskinesia via 5-HT1A receptors.
ISSN:	0306-4522 1873-7544 1873-7544
DOI:	10.1016/j.neuroscience.2013.12.029