Cerebral microvascular effects of nimodipine in combination with soman

Highlights ► Nimodipine and soman elicit marked regional cerebral vasodilation. ► The combination of nimodipine and soman attenuates the microvascular response. ► The nimodipine increased detoxification of soman may be due to a vascular effect.

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Bibliographische Detailangaben
Veröffentlicht in:	Environmental toxicology and pharmacology 2012-11, Vol.34 (3), p.905-910
Hauptverfasser:	Koskinen, Lars-Owe D, Runnerstam, Magnus, Koch, Mona, Karlsson, Britt M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism Animals Cerebral vasospasm Cerebrovascular Circulation - drug effects Cholinesterase Inhibitors - toxicity Emergency Male Microcirculation Microcirculation - drug effects Nimodipine Nimodipine - toxicity Rats Regional Blood Flow - drug effects Regional cerebral blood flow Soman - toxicity Soman intoxication Vascular Resistance - drug effects Vasodilator Agents - toxicity
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Beschreibung
Zusammenfassung:	Highlights ► Nimodipine and soman elicit marked regional cerebral vasodilation. ► The combination of nimodipine and soman attenuates the microvascular response. ► The nimodipine increased detoxification of soman may be due to a vascular effect.
ISSN:	1382-6689 1872-7077 1872-7077
DOI:	10.1016/j.etap.2012.08.008