Sexually dimorphic behavior after developmental exposure to characterize endocrine-mediated effects of different non-dioxin-like PCBs in rats

Highlights ► Feminization of sexually dimorphic sweet preference behavior was observed in male rats after perinatal exposure to PCB95. ► Feminization of sexual dimorphic behavior occurs after purification of PCB congeners to remove Ah receptor activity. ► Different non-dioxin-like PCBs exert differe...

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Veröffentlicht in:	Toxicology (Amsterdam) 2013-09, Vol.311 (1-2), p.52-60
Hauptverfasser:	Lilienthal, Hellmuth, Heikkinen, Päivi, Andersson, Patrik L, Viluksela, Matti
Format:	Artikel
Sprache:	eng
Schlagworte:	adults Animals Animals, Newborn body weight brain breast milk Dioxins Emergency Endocrine disruption Endocrine Disruptors - toxicity energy-dispersive XES Female females feminization femtosecond x-ray spectroscopy humans invertebrates Kβemission lines Male males neonates Polychlorinated biphenyls Polychlorinated Biphenyls - toxicity Pregnancy progeny pups Random Allocation Rat Rats Rats, Long-Evans Rats, Sprague-Dawley saccharin Saccharin - administration & dosage Sex Characteristics sexual dimorphism Sexually dimorphic behavior steroid hormones Sweet preference tap water Taste - drug effects Taste - physiology toxicology unspecific monooxygenase
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Beschreibung
Zusammenfassung:	Highlights ► Feminization of sexually dimorphic sweet preference behavior was observed in male rats after perinatal exposure to PCB95. ► Feminization of sexual dimorphic behavior occurs after purification of PCB congeners to remove Ah receptor activity. ► Different non-dioxin-like PCBs exert differential effects on this behavior.
ISSN:	0300-483X 1879-3185 1879-3185
DOI:	10.1016/j.tox.2013.01.025