Directed diversity-oriented synthesis. Ring-fused 5- to 10-membered rings from a common peptidomimetic 2-pyridone precursor

Directed diversity-oriented synthesis. Ring-fused 5- to 10-membered rings from a common peptidomimetic 2-pyridone precursor

A variety of ring-fused 2-pyridone-based central fragments were prepared using a strategy inspired by diversity-oriented synthesis. The produced compounds are diverse, yet focused, analogs of biologically active peptidomimetic 2-pyridones.

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Veröffentlicht in:Tetrahedron letters 2012-11, Vol.53 (45), p.6022-6024
Hauptverfasser: Sellstedt, Magnus, Krishna Prasad, G., Syam Krishnan, K., Almqvist, Fredrik
Format: Artikel
Sprache:eng
Schlagworte:
2-Pyridone
Diversity-oriented synthesis
Medium-sized rings
Peptidomimetics
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Zusammenfassung:A variety of ring-fused 2-pyridone-based central fragments were prepared using a strategy inspired by diversity-oriented synthesis. The produced compounds are diverse, yet focused, analogs of biologically active peptidomimetic 2-pyridones.
ISSN:0040-4039
1359-8562
1873-3581
DOI:10.1016/j.tetlet.2012.08.100