Insertion sequence 1515 in the ply gene of a type 1 clinical isolate of Streptococcus pneumoniae abolishes pneurnolysin expression

Insertion sequence 1515 in the ply gene of a type 1 clinical isolate of Streptococcus pneumoniae abolishes pneurnolysin expression

Abstract: A serotype 1 Streptococcus pneumoniae strain isolated by blood culture from a woman with pneumonia was found to harbor insertion sequence (IS) 1515 in the pneumolysin gene, abolishing pneumolysin expression. To our knowledge, this is the first report of an IS in the pneumolysin gene of S....

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Veröffentlicht in:Journal of clinical microbiology 2007-07, Vol.45 (7), p.2296
Hauptverfasser: Garnier, Fabien, Janapatla, Rajendra Prasad, Charpentier, Emmanuelle, Masson, Geoffrey, Grélaud, Carole, Stach, Jean François, Denis, François, Ploy, Marie-Cécile
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Sprache:eng
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Zusammenfassung:Abstract: A serotype 1 Streptococcus pneumoniae strain isolated by blood culture from a woman with pneumonia was found to harbor insertion sequence (IS) 1515 in the pneumolysin gene, abolishing pneumolysin expression. To our knowledge, this is the first report of an IS in the pneumolysin gene of S. pneumoniae.
ISSN:1098-660X
0095-1137
DOI:10.1128/JCM.02168-06