Towards quorum-quenching catalytic antibodies

The development of a novel method to attenuate bacterial virulence is reported, which is based upon the use of designed transition-state analogues to select human catalytic antibodies capable of degrading bacterial quorum-sensing molecules.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2009-01 (5), p.538
Hauptverfasser:	Kapadnis, Prashant B, Hall, Evan, Ramstedt, Madeleine, Galloway, Warren R J D, Welch, Martin, Spring, David R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl-Butyrolactones - chemistry Anti-Bacterial Agents - metabolism Antibodies, Catalytic - metabolism Bacterial Proteins - antagonists & inhibitors Hydrolysis Quorum Sensing Sulfones - chemistry
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Beschreibung
Zusammenfassung:	The development of a novel method to attenuate bacterial virulence is reported, which is based upon the use of designed transition-state analogues to select human catalytic antibodies capable of degrading bacterial quorum-sensing molecules.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/b819819e