Gut Microbial Metabolites and Future Risk of Parkinson's Disease: A Metabolome-Wide Association Study

Alterations in gut microbiota are observed in Parkinson's disease (PD). Previous studies on microbiota-derived metabolites in PD were small-scale and post-diagnosis, raising concerns about reverse causality. Our goal was to prospectively investigate the association between plasma microbial meta...

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Veröffentlicht in:	Movement disorders 2024-11
Hauptverfasser:	Zhao, Yujia, Lai, Yunjia, Darweesh, Sirwan K L, Bloem, Bastiaan R, Forsgren, Lars, Hansen, Johnni, Katzke, Verena A, Masala, Giovanna, Sieri, Sabina, Sacerdote, Carlotta, Panico, Salvatore, Zamora-Ros, Raul, Sánchez, Maria-Jose, Huerta, José María, Guevara, Marcela, Vinagre-Aragon, Ana, Vineis, Paolo, Lill, Christina M, Miller, Gary W, Peters, Susan, Vermeulen, Roel
Format:	Artikel
Sprache:	eng
Schlagworte:	gut-brain axis microbial metabolites Parkinson's disease pre-diagnostic biosamples untargeted metabolomics
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Zusammenfassung:	Alterations in gut microbiota are observed in Parkinson's disease (PD). Previous studies on microbiota-derived metabolites in PD were small-scale and post-diagnosis, raising concerns about reverse causality. Our goal was to prospectively investigate the association between plasma microbial metabolites and PD risk within a metabolomics framework. A nested case-control study within the prospective EPIC4PD cohort, measured pre-diagnostic plasma microbial metabolites using untargeted metabolomics. Thirteen microbial metabolites were identified nominally associated with PD risk (P-value
ISSN:	0885-3185 1531-8257 1531-8257
DOI:	10.1002/mds.30054