Capillary density: An important parameter in nailfold capillaroscopy

Nailfold capillaroscopy is one of the various noninvasive bioengineering methods used to investigate skin microcirculation. It is an effective examination for assessing microvascular changes in the peripheral circulation; hence it has a significant role for the diagnosis of Systemic sclerosis with the classic changes of giant capillaries as well as the decline in capillary density with capillary dropout. The decline in capillary density is one of microangiopathic features existing in connective tissue disease. It is detectable with nailfold capillaroscopy. This parameter is assessed by applying quantitative measurement. In this article, we reviewed a common method for calculating the capillary density and the relation between the number of capillaries as well as the existence of digital ulcers, pulmonary arterial hypertension, autoantibodies, scleroderma patterns and different scoring system. •A summary of common methods to calculate the number of capillaries is explained.•The effectiveness of capillary density on autoantibodies, VEGF, SSc-PAH patients and scleroderma patterns is reported•The effectiveness of capillary density in quantitative and semiquantitative scoring system is described.