Breast Cancer Risk Factors and Circulating Anti-Müllerian Hormone Concentration in Healthy Premenopausal Women

Breast Cancer Risk Factors and Circulating Anti-Müllerian Hormone Concentration in Healthy Premenopausal Women

We previously reported that anti-Müllerian hormone (AMH), a marker of ovarian reserve, is positively associated with breast cancer risk, consistent with other studies. This study assessed whether risk factors for breast cancer are correlates of AMH concentration. This cross-sectional study included...

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Veröffentlicht in:The journal of clinical endocrinology and metabolism 2021-11, Vol.106 (11), p.e4542-e4553
Hauptverfasser: Clendenen, Tess V, Ge, Wenzhen, Koenig, Karen L, Afanasyeva, Yelena, Agnoli, Claudia, Bertone-Johnson, Elizabeth, Brinton, Louise A, Darvishian, Farbod, Dorgan, Joanne F, Eliassen, A Heather, Falk, Roni T, Hallmans, Göran, Hankinson, Susan E, Hoffman-Bolton, Judith, Key, Timothy J, Krogh, Vittorio, Nichols, Hazel B, Sandler, Dale P, Schoemaker, Minouk J, Sluss, Patrick M, Sund, Malin, Swerdlow, Anthony J, Visvanathan, Kala, Liu, Mengling, Zeleniuch-Jacquotte, Anne
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aging - blood
AMH correlates
Anti-Mullerian Hormone - blood
anti-Müllerian hormone
Biomarkers
Body Mass Index
Breast cancer
breast cancer risk factors
Breast Diseases - blood
Breast Neoplasms - blood
Cancer
Cohort Studies
Comparative analysis
Cross-Sectional Studies
Female
Health aspects
Hormones
Humans
Menopause
Middle Aged
Oncology, Experimental
Online Only
Oral contraceptives
Ovarian Reserve
Pregnancy
Premenopause - blood
Risk Factors
Women
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Zusammenfassung:We previously reported that anti-Müllerian hormone (AMH), a marker of ovarian reserve, is positively associated with breast cancer risk, consistent with other studies. This study assessed whether risk factors for breast cancer are correlates of AMH concentration. This cross-sectional study included 3831 healthy premenopausal women (aged 21-57, 87% aged 35-49) from 10 cohort studies among the general population. Adjusting for age and cohort, AMH positively associated with age at menarche (P 
ISSN:0021-972X
1945-7197
1945-7197
DOI:10.1210/clinem/dgab461