Selective concentrations for trimethoprim resistance in aquatic environments

•Trimethoprim selects for resistant E. coli at 100 µg/L in complex communities.•Fitness cost of dfr-genes was reduced at 10 µg/L in pairwise competition assays.•Fitness costs are highly dependent on genetic and environmental contexts.•Thus, a reduction in cost is considered a risk, even if some cost...

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Veröffentlicht in:	Environment international 2020-11, Vol.144, p.106083, Article 106083
Hauptverfasser:	Kraupner, Nadine, Ebmeyer, Stefan, Hutinel, Marion, Fick, Jerker, Flach, Carl-Fredrik, Larsson, D.G. Joakim
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibiotic resistance bacteria biofilm ciprofloxacin communities consumption Drug Resistance, Microbial effluent Environmental emission limits Environmental Sciences Environmental Sciences & Ecology Escherichia coli - genetics Humans Infectious Medicine Infektionsmedicin Life Sciences & Biomedicine LOEC Microbiology in the medical area Mikrobiologi inom det medicinska området NOEC penetration pharmaceuticals Science & Technology Trimethoprim - toxicity Trimethoprim Resistance - genetics waste-water
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Zusammenfassung:	•Trimethoprim selects for resistant E. coli at 100 µg/L in complex communities.•Fitness cost of dfr-genes was reduced at 10 µg/L in pairwise competition assays.•Fitness costs are highly dependent on genetic and environmental contexts.•Thus, a reduction in cost is considered a risk, even if some cost still remains.•Keeping exposure of trimethoprim
ISSN:	0160-4120 1873-6750 1873-6750
DOI:	10.1016/j.envint.2020.106083