Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function
We assessed differences in mitochondrial function in gluteal (gSAT) and abdominal subcutaneous adipose tissue (aSAT) at baseline and in response to 12-weeks of exercise training; and examined depot-specific associations with body fat distribution and insulin sensitivity (S I ). Obese, black South Af...
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Veröffentlicht in: | Scientific reports 2020-03, Vol.10 (1), p.3785, Article 3785 |
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Sprache: | eng |
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Zusammenfassung: | We assessed differences in mitochondrial function in gluteal (gSAT) and abdominal subcutaneous adipose tissue (aSAT) at baseline and in response to 12-weeks of exercise training; and examined depot-specific associations with body fat distribution and insulin sensitivity (S
I
). Obese, black South African women (n = 45) were randomized into exercise (n = 23) or control (n = 22) groups. Exercise group completed 12-weeks of aerobic and resistance training (n = 20), while the control group (n = 15) continued usual behaviours. Mitochondrial function (high-resolution respirometry and fluorometry) in gSAT and aSAT, S
I
(frequently sampled intravenous glucose tolerance test), body composition (dual-energy X-ray absorptiometry), and ectopic fat (MRI) were assessed pre- and post-intervention. At baseline, gSAT had higher mitochondrial respiratory capacity and hydrogen peroxide (H
2
O
2
) production than aSAT (p |
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ISSN: | 2045-2322 2045-2322 |
DOI: | 10.1038/s41598-020-60286-x |