Chronic airway obstruction in a population-based adult asthma cohort: Prevalence, incidence and prognostic factors

Asthma and COPD may overlap (ACO) but information about incidence and risk factors are lacking. This study aimed to estimate prevalence, incidence and risk factors of chronic airway obstruction (CAO) in a population-based adult asthma cohort. During 1986–2001 a large population-based asthma cohort w...

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Veröffentlicht in:	Respiratory medicine 2018-05, Vol.138, p.115-122
Hauptverfasser:	Backman, Helena, Jansson, Sven-Arne, Stridsman, Caroline, Muellerova, Hana, Wurst, Keele, Hedman, Linnea, Lindberg, Anne, Rönmark, Eva
Format:	Artikel
Sprache:	eng
Schlagworte:	ACO Adult Age Age Factors Airway management Anti-Asthmatic Agents - therapeutic use Asthma Asthma - complications Asthma - drug therapy Asthma - epidemiology Asthma - physiopathology Body mass index Bronchodilators Cardiovascular disease Chronic obstructive pulmonary disease Coronary artery disease Drug Utilization - statistics & numerical data Epidemiology Female Follow-Up Studies Forced Expiratory Volume - physiology Health risk assessment Health Science Heart Heart diseases Humans Hälsovetenskap Identification methods Incidence Ischemia Leukocytes (neutrophilic) Longitudinal studies Longitudinal study Male Middle Aged Nursing Omvårdnad Population Population-based studies Prevalence Prognosis Pulmonary Disease, Chronic Obstructive - epidemiology Pulmonary Disease, Chronic Obstructive - etiology Pulmonary Disease, Chronic Obstructive - physiopathology Respiratory tract Risk analysis Risk Factors Sensitivity and Specificity Sex Factors Smoking Smoking - adverse effects Smoking - epidemiology Socioeconomic factors Spirometry - methods Sweden - epidemiology Vital Capacity - physiology
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Beschreibung
Zusammenfassung:	Asthma and COPD may overlap (ACO) but information about incidence and risk factors are lacking. This study aimed to estimate prevalence, incidence and risk factors of chronic airway obstruction (CAO) in a population-based adult asthma cohort. During 1986–2001 a large population-based asthma cohort was identified (n = 2055, 19-72y). Subsamples have participated in clinical follow-ups during the subsequent years. The entire cohort was invited to a clinical follow-up including interview, spirometry, and blood sampling in 2012–2014 when n = 983 subjects performed adequate spirometry. CAO was defined as post-bronchodilator FEV1/FVC
ISSN:	0954-6111 1532-3064 1532-3064
DOI:	10.1016/j.rmed.2018.03.036