Synthesis of new transition metal complexes of 1H-perimidine derivatives having antimicrobial and anti-inflammatory activities

New series of 1 H -perimidine-2-thiol derivatives and (2-substituted-1 H -perimidin-1-yl)ethane-1,2-dione derivatives and their ligands (C 24 H 14 N 4 S 2 O 2 ) H 2 L 1 and (C 26 H 18 N 4 S 2 O 2 ) H 2 L 2 have been synthesized with transition metal ions, e.g., Copper (II), Silver (I), Cobalt (II) and Ruthenium (III) were prepared and evaluated for their antimicrobial, analgesic and anti-inflammatory activities. The synthesized compounds and their complexes were characterized by elemental analysis, 1 H NMR, IR, MS, molar conductance, thermal gravimetric analysis and electronic spectra. All results revealed that compounds 3 and 13 exhibited high inhibitory effects against some bacterial strains by the disc diffusion method. On the other hand, compounds 2 , 3 , 7 and 12 displayed potent anti-inflammatory activity.