Highly Compatible Metal and Enzyme Catalysts for Efficient Dynamic Kinetic Resolution of Alcohols at Ambient Temperature

Highly Compatible Metal and Enzyme Catalysts for Efficient Dynamic Kinetic Resolution of Alcohols at Ambient Temperature

The combination of highly compatible metal and enzyme catalysts allows the fastest dynamic kinetic resolution of alcohols ever reported. The use of ruthenium catalyst 1 a (or 1 b) and an immobilized lipase results in a highly efficient enantioselective synthesis of acetates in excellent yields at ro...

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Veröffentlicht in:Angewandte Chemie International Edition 2004-12, Vol.43 (47), p.6535-6539
Hauptverfasser: Martín-Matute, Belén, Edin, Michaela, Bogár, Krisztián, Bäckvall, Jan-E.
Format: Artikel
Sprache:eng
Schlagworte:
Alcohols - chemistry
Alcohols - metabolism
Catalysis
enantioselectivity
enzyme catalysis
kinetic resolution
Kinetics
Lipase - metabolism
Metals - chemistry
Molecular Structure
reaction mechanisms
ruthenium
Temperature
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Beschreibung
Zusammenfassung:The combination of highly compatible metal and enzyme catalysts allows the fastest dynamic kinetic resolution of alcohols ever reported. The use of ruthenium catalyst 1 a (or 1 b) and an immobilized lipase results in a highly efficient enantioselective synthesis of acetates in excellent yields at room temperature (see scheme).
ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.200461416