Effect of Chain Density on Inhibition of Protein Adsorption by Poly(ethylene glycol) Based Coatings

The effect of interfacial chain density of poly(ethylene glycol) (PEG) on the adsorption of serum proteins was investigated byin situellipsometry. For terminal covalently grafted PEG of molecular weight 5000 an increased grafting density results in decreased serum protein adsorption. At high interfa...

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Veröffentlicht in:	Journal of Colloid and Interface Science 1998-06, Vol.202 (2), p.507-517
Hauptverfasser:	Malmsten, Martin, Emoto, Ken, Van Alstine, James M.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADSORPTION Applied sciences Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGY AND MEDICINE, APPLIED STUDIES COATINGS ellipsometry ellipsometry: PEG Exact sciences and technology Fundamental and applied biological sciences. Psychology GLYCOLS Miscellaneous Molecular biophysics Organic polymers PEG Physicochemistry of polymers poly(ethylene glycol) polymer Properties and characterization protein PROTEINS Surface properties. Adsorption
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Zusammenfassung:	The effect of interfacial chain density of poly(ethylene glycol) (PEG) on the adsorption of serum proteins was investigated byin situellipsometry. For terminal covalently grafted PEG of molecular weight 5000 an increased grafting density results in decreased serum protein adsorption. At high interfacial chain density (≈0.1 chain/nm2), efficient protein rejection was observed, irrespective of the coupling chemistry used. Strongly adsorbed PEG-containing polymers behaved similarly to covalently attached PEG regarding inhibition of protein adsorption, independent of the nature of the underlying surface. The results are discussed in relation to the importance of the protein size in protein rejection by PEG coatings.
ISSN:	0021-9797 1095-7103 1095-7103
DOI:	10.1006/jcis.1998.5513