Selective thioacylation of amines in water: a convenient preparation of secondary thioamides and thiazolines

Selective thioacylation of amines in water: a convenient preparation of secondary thioamides and thiazolines

Primary thioamides have been utilised directly in water, without any derivatisation, to selectively thioacylate primary amines. By employing 2-hydroxyethylamines, the reaction can be extended to the preparation of 2-thiazolines via formation of β-hydroxythioamides.

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Veröffentlicht in:RSC advances 2015-01, Vol.5 (6), p.4484-4488
Hauptverfasser: Pathak, Uma, Bhattacharyya, Shubhankar, Mathur, Sweta
Format: Artikel
Sprache:eng
Schlagworte:
Amines
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Zusammenfassung:Primary thioamides have been utilised directly in water, without any derivatisation, to selectively thioacylate primary amines. By employing 2-hydroxyethylamines, the reaction can be extended to the preparation of 2-thiazolines via formation of β-hydroxythioamides.
ISSN:2046-2069
2046-2069
DOI:10.1039/C4RA13097A