The role of the cytoskeletal proteins MreB and FtsZ in multicellular cyanobacteria

Among the myriad of cyanobacterial shapes and sizes, Stigonematales show the highest complexity as they present different cell shapes and sizes within a single cyanobacterial strain. By studying the main cytoskeletal components in these cyanobacteria, we aim to understand how cells undergo these cha...

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Veröffentlicht in:FEBS open bio 2020-12, Vol.10 (12), p.2510-2531
Hauptverfasser: Springstein, Benjamin L., Weissenbach, Julia, Koch, Robin, Stücker, Fenna, Stucken, Karina
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Sprache:eng
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Zusammenfassung:Among the myriad of cyanobacterial shapes and sizes, Stigonematales show the highest complexity as they present different cell shapes and sizes within a single cyanobacterial strain. By studying the main cytoskeletal components in these cyanobacteria, we aim to understand how cells undergo these changes. We provide the first insights on the role of the cytoskeletal proteins MreB and FtsZ in cyanobacterial morphogenesis. Multiseriate and true‐branching cyanobacteria are at the peak of prokaryotic morphological complexity. However, little is known about the mechanisms governing multiplanar cell division and morphogenesis. Here, we study the function of the prokaryotic cytoskeletal proteins, MreB and FtsZ in Fischerella muscicola PCC 7414 and Chlorogloeopsis fritschii PCC 6912. Vancomycin and HADA labeling revealed a mixed apical, septal, and lateral trichome growth mode in F. muscicola, whereas C. fritschii exhibits septal growth. In all morphotypes from both species, MreB forms either linear filaments or filamentous strings and can interact with FtsZ. Furthermore, multiplanar cell division in F. muscicola likely depends on FtsZ dosage. Our results lay the groundwork for future studies on cytoskeletal proteins in morphologically complex cyanobacteria.
ISSN:2211-5463
2211-5463
DOI:10.1002/2211-5463.13016