Intraepithelial lymphocyte distribution differs between the bulb and the second part of duodenum

Evaluation of intraepithelial duodenal lymphocytosis (IDL) is important in celiac disease (CD). There is no established cut-off value for increased number of IELs in the bulb.We therefore investigated the relation between IEL counts in the bulb and duodenal specimens in non-celiac subjects. The numb...

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Veröffentlicht in:	BMC gastroenterology 2013-07, Vol.13 (1), p.111-111, Article 111
Hauptverfasser:	Bednarska, Olga, Ignatova, Simone, Dahle, Charlotte, Ström, Magnus
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Analysis Antibodies CD3 Complex - metabolism Confidence intervals Duodenal Diseases - immunology Duodenal Diseases - pathology Duodenum Duodenum - cytology Duodenum - immunology Duodenum - metabolism Epithelium - immunology Female Gastroenterology Genotype GTP-Binding Proteins Health sciences Hepatology Histology HLA-DQ Antigens - genetics Hospitals Humans Immunoglobulin A - blood Lymphocyte Count Lymphocytes Lymphocytes - metabolism Lymphocytosis - immunology Lymphocytosis - pathology Male MEDICIN MEDICINE Middle Aged Patients Transglutaminases - immunology Viral antibodies
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Zusammenfassung:	Evaluation of intraepithelial duodenal lymphocytosis (IDL) is important in celiac disease (CD). There is no established cut-off value for increased number of IELs in the bulb.We therefore investigated the relation between IEL counts in the bulb and duodenal specimens in non-celiac subjects. The number of CD3+ IELs was determined in specimens from the second part of the duodenum and from the bulb in 34 non-celiac subjects. The numbers of IELs in the villus tip and sides were counted and the quotient tip/side was calculated. HLA DQ2/DQ8 and serum antibodies against transglutaminase were analysed. The mean number of IELs per 100 enterocytes (95% CI) in specimens was 14.7 (11.8-17.6) in the bulb, and 21.2 (17.0-25.5) in the second part of the duodenum (p
ISSN:	1471-230X 1471-230X
DOI:	10.1186/1471-230X-13-111