Autophagy regulates trans fatty acid-mediated apoptosis in primary cardiac myofibroblasts

Trans fats are not a homogeneous group of molecules and less is known about the cellular effects of individual members of the group. Vaccenic acid (VA) and elaidic acid (EA) are the predominant trans monoenes in ruminant fats and vegetable oil, respectively. Here, we investigated the mechanism of ce...

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Veröffentlicht in:	Biochimica et biophysica acta 2012-12, Vol.1823 (12), p.2274-2286
Hauptverfasser:	Ghavami, Saeid, Cunnington, Ryan H., Yeganeh, Behzad, Davies, Jared J.L., Rattan, Sunil G., Bathe, Krista, Kavosh, Morvarid, Los, Marek J., Freed, Darren H., Klonisch, Thomas, Pierce, Grant N., Halayko, Andrew J., Dixon, Ian M.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Autophagy Blotting, Western Cells, Cultured Elaidic acid Flow Cytometry Heart Ventricles - drug effects Heart Ventricles - pathology Male Membrane Potential, Mitochondrial - drug effects Myofibroblast Myofibroblasts - drug effects Myofibroblasts - pathology Proto-Oncogene Proteins c-bcl-2 - metabolism Rats Rats, Sprague-Dawley Trans fat Trans Fatty Acids - pharmacology Vaccenic acid
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Beschreibung
Zusammenfassung:	Trans fats are not a homogeneous group of molecules and less is known about the cellular effects of individual members of the group. Vaccenic acid (VA) and elaidic acid (EA) are the predominant trans monoenes in ruminant fats and vegetable oil, respectively. Here, we investigated the mechanism of cell death induced by VA and EA on primary rat ventricular myofibroblasts (rVF). The MTT assay demonstrated that both VA and EA (200μM, 0–72h) reduced cell viability in rVF (P
ISSN:	0167-4889 0006-3002 1879-2596 1879-2596
DOI:	10.1016/j.bbamcr.2012.09.008