LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma

Highlights ► LTBP-2 was significantly down-regulated in NPC cell lines and biopsies. ► LTBP-2 silencing is associated with promoter hypermethylation. ► LTBP-2 suppresses malignancy by impairing in vitro & in vivo cell growth properties. ► LTBP-2 pleiotropically inhibits angiogenesis, VEGF secret...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2012-12, Vol.325 (1), p.89-98
Hauptverfasser:	Chen, Han, Ko, Josephine Mun Yee, Wong, Victor Chun Lam, Hyytiainen, Marko, Keski-Oja, Jorma, Chua, Daniel, Nicholls, John M, Cheung, Florence Man Fung, Lee, Anne Wing Mui, Kwong, Dora Lai-wan, Chiu, Pui Man, Zabarovsky, Eugene R, Tsao, Sai Wah, Tao, Qian, Kan, Rebecca, Chan, Stephen Ho Kin, Stanbridge, Eric J, Lung, Maria Li
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Anti-angiogenesis Azacitidine - analogs & derivatives Azacitidine - pharmacology Carcinoma Cell adhesion & migration Cell growth Cell Line, Tumor cell movement Cell Movement - physiology Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cloning Colonies & territories Decitabine DNA Methylation dormancy Down-Regulation - genetics Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Humans Hydroxamic Acids - pharmacology Latent TGF-beta Binding Proteins - genetics Latent TGF-beta Binding Proteins - metabolism Latent transforming growth factor beta binding protein 2 (LTBP-2) Latent transforming growth factor β binding protein 2 (LTBP-2) Lymphatic system Metastatic growth Nasopharyngeal Carcinoma Nasopharyngeal carcinoma (NPC) Nasopharyngeal Neoplasms - blood supply Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - pathology Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Plasmids Promoter Regions, Genetic Proteins secretion Seeds Technological change TECHNOLOGY TEKNIKVETENSKAP Tumor cell dormancy Tumor Microenvironment Tumor suppression Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tumors Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights ► LTBP-2 was significantly down-regulated in NPC cell lines and biopsies. ► LTBP-2 silencing is associated with promoter hypermethylation. ► LTBP-2 suppresses malignancy by impairing in vitro & in vivo cell growth properties. ► LTBP-2 pleiotropically inhibits angiogenesis, VEGF secretion and migration. ► LTBP-2 confers tumor cell dormancy in microenvironment favorable for metastasis.
ISSN:	0304-3835 1872-7980 1872-7980
DOI:	10.1016/j.canlet.2012.06.005