Ferrocene-mediated enzyme electrode for amperometric determination of glucose

Ferrocene-mediated enzyme electrode for amperometric determination of glucose

An amperometric enzyme electrode for the analysis of glucose is described. The electrode uses a substituted ferricinium ion as a mediator of electron transfer between immobilized glucose oxidase and a graphite electrode. A linear current response, proportional to the glucose concentration over a ran...

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Veröffentlicht in:Analytical chemistry (Washington) 1984-04, Vol.56 (4), p.667-671
Hauptverfasser: Cass, Anthony E. G, Davis, Graham, Francis, Graeme D, Hill, H. Allen O, Aston, William J, Higgins, I. John, Plotkin, Elliot V, Scott, Lesley D. L, Turner, Anthony P. F
Format: Artikel
Sprache:eng
Schlagworte:
Blood Glucose - analysis
Diabetes Mellitus - blood
Electrodes
Enzymes, Immobilized
Ferrous Compounds
glucose
Glucose Oxidase
Humans
immobilized enzymes
Iron
Metallocenes
Organometallic Compounds
TECHNOLOGY
TEKNIKVETENSKAP
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Beschreibung
Zusammenfassung:An amperometric enzyme electrode for the analysis of glucose is described. The electrode uses a substituted ferricinium ion as a mediator of electron transfer between immobilized glucose oxidase and a graphite electrode. A linear current response, proportional to the glucose concentration over a range commonly found in diabetic blood samples (1-30 mM), is observed. Data are presented on the influence of oxygen, pH, and temperature upon the electrode. Results with clinical plasma and whole blood samples show good agreement with a standard method of analysis.
ISSN:0003-2700
1520-6882
1520-6882
DOI:10.1021/ac00268a018