Anaemia and renal dysfunction are independently associated with BNP and NT-proBNP levels in patients with heart failure

Anaemia and renal dysfunction are independently associated with BNP and NT-proBNP levels in patients with heart failure

Background Anaemia may affect B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) levels, but this has not been well described in heart failure (HF) patients without the exclusion of patients with renal dysfunction. Aims To study the influence of both anaemia and renal function on BNP...

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Veröffentlicht in:European journal of heart failure 2007-08, Vol.9 (8), p.787-794
Hauptverfasser: Hogenhuis, Jochem, Voors, Adriaan A., Jaarsma, Tiny, Hoes, Arno W., Hillege, Hans L., Kragten, Johannes A., van Veldhuisen, Dirk J.
Format: Artikel
Sprache:eng
Schlagworte:
Aged
anaemia
Anemia - blood
BNP
Creatinine - blood
Female
Glomerular Filtration Rate
heart failure
Heart Failure - blood
Humans
Kidney Diseases - blood
Male
Middle Aged
Multivariate Analysis
Natriuretic Peptide, Brain - blood
NT-proBNP
Peptide Fragments - blood
renal dysfunction
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Zusammenfassung:Background Anaemia may affect B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) levels, but this has not been well described in heart failure (HF) patients without the exclusion of patients with renal dysfunction. Aims To study the influence of both anaemia and renal function on BNP and NT-proBNP levels in a large group of hospitalised HF patients. Methods and results We studied 541 patients hospitalised for HF (mean age 71±11 years, 62% male, and left ventricular ejection fraction 0.33±0.14). Of these patients, 30% (n=159) were anaemic (women: Hb
ISSN:1388-9842
1879-0844
1879-0844
DOI:10.1016/j.ejheart.2007.04.001