Chronic amitriptyline treatment induces hippocampal NGFI-A, glucocorticoid receptor and mineralocorticoid receptor mRNA expression in rats

Adult male rats were treated with the antidepressant drug amitriptyline for 21 days and the expression of specific transcription factors was examined. NGFI-A mRNA expression was increased in the hippocampus and in the cerebral cortex. MR mRNA was increased in the hippocampus while GR mRNA was increa...

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Veröffentlicht in:	Brain research. Molecular brain research. 1998-11, Vol.62 (1), p.92-95
Hauptverfasser:	Johansson, Inga-Maj, Bjartmar, Lisa, Marcusson, Jan, Ross, Svante B, Seckl, Jonathan R, Olsson, Tommy
Format:	Artikel
Sprache:	eng
Schlagworte:	Amitriptyline - administration & dosage Amitriptyline - pharmacology Animals Antidepressant Antidepressive Agents, Tricyclic Biological and medical sciences DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Early Growth Response Protein 1 Gene Expression Regulation - drug effects Glucocorticoid receptor Hippocampus Hippocampus - chemistry Hippocampus - drug effects Hippocampus - metabolism Immediate-Early Proteins Injections, Subcutaneous Male Medical sciences MEDICIN MEDICINE Neuronal Plasticity - drug effects Neuropharmacology NGFI-A Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Sprague-Dawley Receptors, Glucocorticoid - biosynthesis Receptors, Glucocorticoid - genetics Receptors, Mineralocorticoid - biosynthesis Receptors, Mineralocorticoid - genetics RNA, Messenger - analysis RNA, Messenger - biosynthesis Transcription factor Transcription Factors - biosynthesis Transcription Factors - genetics Transcription Factors - physiology
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Beschreibung
Zusammenfassung:	Adult male rats were treated with the antidepressant drug amitriptyline for 21 days and the expression of specific transcription factors was examined. NGFI-A mRNA expression was increased in the hippocampus and in the cerebral cortex. MR mRNA was increased in the hippocampus while GR mRNA was increased in selective hippocampal regions. There was no change in the NGFI-B mRNA expression. Thus, NGFI-A may be a mediator of plasticity-related phenomena induced by antidepressant drugs.
ISSN:	0169-328X 1872-6941 1872-6941
DOI:	10.1016/S0169-328X(98)00243-5