Prostaglandin E 2 Production by Brain Endothelial Cells and the Generation of Fever

Prostaglandin E 2 Production by Brain Endothelial Cells and the Generation of Fever

We recently demonstrated that prostaglandin production in brain endothelial cells is both necessary and sufficient for the generation of fever during systemic immune challenge. I here discuss this finding in light of the previous literature and point to some unresolved issues.

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Veröffentlicht in:DNA and cell biology 2023-03, Vol.42 (3), p.107-112
1. Verfasser: Blomqvist, Anders
Format: Artikel
Sprache:eng
Schlagworte:
Brain - metabolism
Cyclooxygenase 2 - metabolism
Endothelial Cells - metabolism
Fever
Humans
Lipopolysaccharides
Prostaglandins
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Zusammenfassung:We recently demonstrated that prostaglandin production in brain endothelial cells is both necessary and sufficient for the generation of fever during systemic immune challenge. I here discuss this finding in light of the previous literature and point to some unresolved issues.
ISSN:1044-5498
1557-7430
1557-7430
DOI:10.1089/dna.2022.0662