Antibiotic administration in targeted nanoparticles protects the faecal microbiota of mice

Antibiotic therapy comes with disturbances on human microbiota, resulting in changes of bacterial communities and thus leading to well-established health problems. In this study, we demonstrated that targeted teicoplanin administration maintains the faecal microbiota composition undisturbed in a mouse model while reaching therapeutic improvements for S. aureus infection. Teicoplanin doped and aptamer-gate functionalized mesoporous silica nanoparticles targeted Staphylococcus aureus and reduced the infection load successfully. However, microbiota communities were undisturbed while free teicoplanin caused dysbiosis.