Nuclease activity as a specific biomarker for breast cancer

We report on the activity of nucleases derived from cancer cells as a means for specific targeting using nucleic acid probes (substrates). We hypothesize that cancer cells can be differentiated from healthy cells based on their nuclease activity profile, and thus, any method based on this property r...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (83), p.12346-12349
Hauptverfasser:	Hernandez, Luiza I, Ozalp, Veli Cengiz, Hernandez, Frank J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Biomarkers, Tumor - analysis Biomarkers, Tumor - metabolism Breast Breast Neoplasms - diagnosis Breast Neoplasms - enzymology Cancer Deoxyribonucleases - analysis Deoxyribonucleases - metabolism Diagnostic systems Female Humans Nuclease Nucleic Acid Probes - chemistry Nucleic Acid Probes - metabolism Nucleic acids Substrates
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Beschreibung
Zusammenfassung:	We report on the activity of nucleases derived from cancer cells as a means for specific targeting using nucleic acid probes (substrates). We hypothesize that cancer cells can be differentiated from healthy cells based on their nuclease activity profile, and thus, any method based on this property represents a novel alternative for diagnostic and therapeutic intervention.
ISSN:	1359-7345 1364-548X 1364-548X
DOI:	10.1039/c6cc07108b