Large variation in blood flow between left ventricular segments, as detected by adenosine stress dynamic CT perfusion

Summary Background Dynamic cardiac CT perfusion (CTP) is based on repeated imaging during the first‐pass contrast agent inflow. It is a relatively new method that still needs validation. Purpose To evaluate the variation in adenosine stress dynamic CTP blood flow as compared to 99mTc SPECT. Secondarily, to compare manual and automatic segmentation. Methods Seventeen patients with manifest coronary artery disease were included. Nine were excluded from evaluation for various reasons. All patients were examined with dynamic stress CTP and stress/rest SPECT. CTP blood flow was compared with SPECT on a per segment basis. Results for manual and automated AHA segmentation were compared. Results CTP showed a positive correlation with SPECT, with correlation coefficients of 0·38 and 0·41 for manual and automatic segmentation, respectively (P