Laser Delivery and Spectral Study of a Chlorine-Containing Drug for the Treatment of Onychomycosis at Sequential Laser (λ = 2810 nm) and Photodynamic (λ = 656 ± 10 nm) Impact

The possibility of a dual-stage active laser delivery of a modern chlorine-containing photodynamic drug under the nail plate for the purpose of photodynamic therapy of onychomycosis has been investigated and demonstrated for the first time. The extinction spectra of the photodynamic drug Revixan (OOO Areal, Russia) are studied at different temperatures, as well as before and after exposure to Er:YLF laser radiation with a wavelength of 2810 nm and photodynamic LED radiation with a wavelength of 656 ± 10 nm. It is shown that after heating and laser exposure, the amount of monomers in the chlorine-containing photodynamic drug increases, and after photodynamic exposure decreases, which can affect the effectiveness of photodynamic therapy of onychomycosis.