Altered Expression of 14-3-3 Genes in the Prefrontal Cortex of Subjects with Schizophrenia: Clinical Research

Altered Expression of 14-3-3 Genes in the Prefrontal Cortex of Subjects with Schizophrenia: Clinical Research

Seven distinct 14-3-3 proteins are expressed in mammals. One of the 14-3-3 genes (eta) has been previously associated with decreased expression in the prefrontal cortex (PFC) of subjects with schizophrenia. DNA microarray analysis of the PFC of 10 subjects with schizophrenia and 10 matched controls...

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Veröffentlicht in:Neuropsychopharmacology (New York, N.Y.) N.Y.), 2005-05, Vol.30 (5), p.974-983
Hauptverfasser: Middleton, Frank A, Peng, Lansha, Lewis, David A, Levitt, Pat, Mirnics, Karoly
Format: Artikel
Sprache:eng
Schlagworte:
Behavioral Sciences
Biological Psychology
Medicine
Medicine & Public Health
Neurosciences
original-article
Pharmacotherapy
Psychiatry
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Zusammenfassung:Seven distinct 14-3-3 proteins are expressed in mammals. One of the 14-3-3 genes (eta) has been previously associated with decreased expression in the prefrontal cortex (PFC) of subjects with schizophrenia. DNA microarray analysis of the PFC of 10 subjects with schizophrenia and 10 matched controls indicated that the majority of 14-3-3 genes exhibited moderate to marked decreases in expression in schizophrenia, which were significant at the group level across all 10 comparisons ( p
ISSN:0893-133X
1740-634X
DOI:10.1038/sj.npp.1300674